My career in cell biology has focused on studying haematopoietic stem cells (HSCs) first using mouse models during my PhD with Prof. Andreas Trumpp in Lausanne, then with Dr John Dick in Toronto during my post-doctoral studies. There I established robust methods to study the function and molecular make-up of human HSCs. In 2014, I moved to the Cambridge Stem Cell Institute where I established my own laboratory thanks to a Wellcome – Royal Society Sir Henry Dale Fellowship. My research aims to understand how HSC function is regulated at all stages of human life to eventually improve treatment of blood diseases. More specifically, my laboratory currently focuses on i) understanding how the functional output of the human HSC pool changes over a human lifetime, at steady-state and under inflammatory conditions; ii) characterising the molecular regulation of quiescence and its relevance to HSC ex vivo expansion and gene therapy.