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“Transcriptional and epigenetic control of blood specification”

“Transcriptional and epigenetic control of blood specification”

Event Date
7 February 2019 - 12:00 to 13:00
Location
SCRM Seminar Room
Speaker Name
Catherine Porcher
Speaker Organisation
MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford

Catherine Porcher is Associate Professor of Developmental and Stem Cell Biology at the University of Oxford, UK.

She received her PhD from University of Paris VII, where she studied red blood cell differentiation through the regulation of genes involved in the haem biosynthetic pathway. She then joined Prof Stuart Orkin’s group at Harvard University (Boston) for her post-doctoral training. There, she developed a broader interest in haematopoiesis and unveiled the essential function of the regulator SCL/TAL1 in the development of all blood lineages, placing it at the apex of the haematopoietic transcriptional hierarchy.

In 1999, she joined the MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine (WIMM) at Oxford University as a group leader.  She pursed her studies of SCL and its role in the transcriptional control of red blood cell and megakaryocyte differentiation. In 2008, she was promoted to tenured PI. She became University Lecturer and, then, Assistant Professor.

Her more recent research focuses on the molecular mechanisms underlying specification of the blood lineage from mesoderm using mouse and Xenopus models.  She also aims at modeling the development of the haematopoietic stem cell (HSC) lineage in vitro from mouse and human pluripotent stem cells.

 

Catherine receives funding from the MRC, BBSRC, BHF.