Leading science, pioneering therapies

Thymus generation and regeneration group publications

2017

Sipp D, Caulfield T, Kaye J, Barfoot J, C Blackburn C, Chan S, De Luca M, Kent A, McCabe C, Munsie M et al..  2017.  Marketing of unproven stem cell-based interventions: A call to action.Sci Transl Med. 9(397)

2016

Vaidya HJayesh, Leon ABriones, C Blackburn C.  2016.  FOXN1 in thymus organogenesis and development.Eur J Immunol. 46(8):1826-37.
Luis TC, Luc S, Mizukami T, Boukarabila H, Thongjuea S, Woll PS, Azzoni E, Giustacchini A, Lutteropp M, Bouriez-Jones T et al..  2016.  Initial seeding of the embryonic thymus by immune-restricted lympho-myeloid progenitors.Nat Immunol. 17(12):1424-1435.
O'Neill KE, Bredenkamp N, Tischner C, Vaidya HJ, Stenhouse FH, Peddie D, Nowell CS, Gaskell T, C Blackburn C.  2016.  Foxn1 Is Dynamically Regulated in Thymic Epithelial Cells during Embryogenesis and at the Onset of Thymic Involution.PLoS One. 11(3):e0151666.
Ulyanchenko S, O'Neill KE, Medley T, Farley AM, Vaidya HJ, Cook AM, Blair NF, C Blackburn C.  2016.  Identification of a Bipotent Epithelial Progenitor Population in the Adult Thymus.Cell Rep. 14(12):2819-32.

2015

Bredenkamp N, Jin X, Liu D, O'Neill KE, Manley NR, C Blackburn C.  2015.  Construction of a functional thymic microenvironment from pluripotent stem cells for the induction of central tolerance.Regen Med. 10(3):317-29.

2014

Jin X, Nowell CS, Ulyanchenko S, Stenhouse FH, C Blackburn C.  2014.  Long-Term Persistence of Functional Thymic Epithelial Progenitor Cells In Vivo under Conditions of Low FOXN1 Expression.PLoS One. 9(12):e114842.
Sheridan JM, C Blackburn C.  2014.  Generation of tissue organoids by compaction reaggregation.Methods Mol Biol. 1092:143-51.
Gordon J, Moore BA, C Blackburn C, Manley NR.  2014.  Serum-free culture of mid-gestation mouse embryos: a tool for the study of endoderm-derived organs.Methods Mol Biol. 1092:183-94.
Bredenkamp N, Ulyanchenko S, O'Neill KE, Manley NRuth, Vaidya HJayesh, C Blackburn C.  2014.  An organized and functional thymus generated from FOXN1-reprogrammed fibroblasts.Nat Cell Biol. 16(9):902-8.
Bredenkamp N, Nowell CS, C Blackburn C.  2014.  Regeneration of the aged thymus by a single transcription factor.Development. 141(8):1627-37.

2013

Garfin PM, Min D, Bryson JL, Serwold T, Edris B, C Blackburn C, Richie ER, Weinberg KI, Manley NR, Sage J et al..  2013.  Inactivation of the RB family prevents thymus involution and promotes thymic function by direct control of Foxn1 expression.J Exp Med. 210(6):1087-97.
Farley A, Morris LX, Vroegindeweij E, Depreter MGL, Vaidya HJayesh, Stenhouse FH, Tomlinson SR, Anderson RA, Cupedo T, Cornelissen JJ et al..  2013.  Dynamics of thymus organogenesis and colonization in early human development.Development. 140(9):2015-26.

2012

Luc S, Luis TC, Boukarabila H, Macaulay IC, Buza-Vidas N, Bouriez-Jones T, Lutteropp M, Woll PS, Loughran SJ, Mead AJ et al..  2012.  The earliest thymic T cell progenitors sustain B cell and myeloid lineage potential.Nat Immunol. 13(4):412-9.
Chinn IK, C Blackburn C, Manley NR, Sempowski GD.  2012.  Changes in primary lymphoid organs with aging.Semin Immunol. 24(5):309-20.

2011

Nowell CS, Bredenkamp N, Tetélin S, Jin X, Tischner C, Vaidya HJayesh, Sheridan JM, Stenhouse FH, Heussen R, Smith AJH et al..  2011.  Foxn1 regulates lineage progression in cortical and medullary thymic epithelial cells but is dispensable for medullary sublineage divergence.PLoS Genet. 7(11):e1002348.
Manley NR, Richie E, C Blackburn C, Condie BGene, Sage J.  2011.  Structure and function of the thymic microenvironment.Front Biosci (Landmark Ed). 16:2461-77.

2010

Foster KE, Gordon J, Cardenas K, Veiga-Fernandes H, Makinen T, Grigorieva EF, Wilkinson DG, C Blackburn C, Richie E, Manley NR et al..  2010.  EphB-ephrin-B2 interactions are required for thymus migration during organogenesis.Proc Natl Acad Sci U S A. 107(30):13414-9.
Bonfanti P, Claudinot S, Amici AW, Farley A, C Blackburn C, Barrandon Y.  2010.  Microenvironmental reprogramming of thymic epithelial cells to skin multipotent stem cells.Nature. 466(7309):978-82.
Liu Z, Farley A, Chen L, Kirby BJ, Kovacs CS, C Blackburn C, Manley NR.  2010.  Thymus-associated parathyroid hormone has two cellular origins with distinct endocrine and immunological functions.PLoS Genet. 6(12):e1001251.

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