Leading science, pioneering therapies

Stem cells and regenerative neurology group publications


Hasel P, Dando O, Jiwaji Z, Baxter P, Todd AC, Heron S, Márkus NM, McQueen J, Hampton DW, Torvell M et al..  2017.  Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism.Nat Commun. 8:15132.
Selvaraj BT, Livesey MR, Chandran S.  2017.  Modeling the C9ORF72 repeat expansion mutation using human induced pluripotent stem cells.Brain Pathol. 27(4):518-524.
Black HA, Leighton DJ, Cleary EM, Rose E, Stephenson L, Colville S, Ross D, Warner J, Porteous M, Gorrie GH et al..  2017.  Genetic epidemiology of motor neuron disease-associated variants in the Scottish population.Neurobiol Aging. 51:178.e11-178.e20.


Qiu J, McQueen J, Bilican B, Dando O, Magnani D, Punovuori K, Selvaraj BT, Livesey M, Haghi G, Heron S et al..  2016.  Evidence for evolutionary divergence of activity-dependent gene expression in developing neurons.Elife. 5
Cleary EM, Pal S, Azam T, Moore DJ, Swingler R, Gorrie G, Stephenson L, Colville S, Chandran S, Porteous M et al..  2016.  Improved PCR based methods for detecting C9orf72 hexanucleotide repeat expansions.Mol Cell Probes.
Sances S, Bruijn LI, Chandran S, Eggan K, Ho R, Klim JR, Livesey MR, Lowry E, Macklis JD, Rushton D et al..  2016.  Modeling ALS with motor neurons derived from human induced pluripotent stem cells.Nat Neurosci. 16(4):542-53.
Mollereau B, Rzechorzek NM, Roussel BD, Sedru M, Van den Brink D, Bailly-Maitre B, Palladino F, Medinas DB, Domingos PM, Hunot S et al..  2016.  Adaptive preconditioning in neurological diseases - Therapeutic insights from proteostatic perturbations.Brain Res.
Rzechorzek NM, Connick P, Livesey MR, Borooah S, Patani R, Burr K, Story D, Wyllie DJA, Hardingham GE, Chandran S.  2016.  Hypothermic Preconditioning Reverses Tau Ontogenesis in Human Cortical Neurons and is Mimicked by Protein Phosphatase 2A Inhibition.EBioMedicine. 3:141-54.
Livesey MR, Magnani D, Cleary EM, Vasistha NA, James OT, Selvaraj BT, Burr K, Story D, Shaw CE, Kind PC et al..  2016.  Maturation and electrophysiological properties of human pluripotent stem cell-derived oligodendrocytes.Stem Cells.


Vesterinen HM, Connick P, Irvine CMJ, Sena ES, Egan KJ, Carmichael GG, Tariq A, Pavitt S, Chataway J, Macleod MR et al..  2015.  Drug repurposing: a systematic approach to evaluate candidate oral neuroprotective interventions for secondary progressive multiple sclerosis.PLoS One. 10(4):e0117705.
Livesey MR, Magnani D, Hardingham GE, Chandran S, Wyllie DJA.  2015.  Functional properties of in vitro excitatory cortical neurons derived from human pluripotent stem cellsThe Journal of Physiology. :n/a-n/a.
Radakovic R, Stephenson L, Colville S, Swingler R, Chandran S, Abrahams S.  2015.  Multidimensional apathy in ALS: validation of the Dimensional Apathy ScaleJournal of Neurology, Neurosurgery & Psychiatry. :jnnp-2015-310772.
Rzechorzek NM, Connick P, Patani R, Selvaraj BT, Chandran S.  2015.  Hypothermic Preconditioning of Human Cortical Neurons Requires Proteostatic Priming.EBioMedicine. 2(6):528-35.
Radakovic R, Stephenson L, Colville S, Swingler R, Chandran S, Abrahams S.  2015.  Multidimensional apathy in ALS: validation of the Dimensional Apathy Scale.J Neurol Neurosurg Psychiatry.
Niven E, Newton J, Foley J, Colville S, Swingler R, Chandran S, Bak TH, Abrahams S.  2015.  Validation of the Edinburgh Cognitive and Behavioural Amyotrophic Lateral Sclerosis Screen (ECAS): A cognitive tool for motor disorders.Amyotroph Lateral Scler Frontotemporal Degener. :1-8.
Bell KFS, Al-Mubarak B, Martel M-A, McKay S, Wheelan N, Hasel P, Márkus NM, Baxter P, Deighton RF, Serio A et al..  2015.  Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2.Nat Commun. 6:7066.
Gamal W, Borooah S, Smith S, Underwood I, Srsen V, Chandran S, Bagnaninchi PO, Dhillon B.  2015.  Real-time quantitative monitoring of hiPSC-based model of macular degeneration on Electric Cell-substrate Impedance Sensing microelectrodes.Biosens Bioelectron. 71:445-55.
Devlin A-C, Burr K, Borooah S, Foster JD, Cleary EM, Geti I, Vallier L, Shaw CE, Chandran S, Miles GB.  2015.  Human iPSC-derived motoneurons harbouring TARDBP or C9ORF72 ALS mutations are dysfunctional despite maintaining viability.Nat Commun. 6:5999.


James OT, Livesey MR, Qiu J, Dando O, Bilican B, Haghi G, Rajan R, Burr K, Hardingham GE, Chandran S et al..  2014.  Ionotropic GABA and glycine receptor subunit composition in human pluripotent stem cell-derived excitatory cortical neurones.J Physiol.
Livesey MR, Bilican B, Qiu J, Rzechorzek NM, Haghi G, Burr K, Hardingham GE, Chandran S, Wyllie DJA.  2014.  Maturation of AMPAR composition and the GABAAR reversal potential in hPSC-derived cortical neurons.J Neurosci. 34(11):4070-5.