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Stem cell genome engineering group publications

2015

Economou C, Tsakiridis A, Wymeersch FJ, Gordon-Keylock S, Dewhurst RE, Fisher D, Medvinsky A, Smith AJH, Wilson V.  2015.  Intrinsic factors and the embryonic environment influence the formation of extragonadal teratomas during gestation.BMC Dev Biol. 15(1):35.

2013

Davies OR, Lin C-Y, Radzisheuskaya A, Zhou X, Taube J, Blin G, Waterhouse A, Smith AJH, Lowell S.  2013.  Tcf15 primes pluripotent cells for differentiation.Cell Rep. 3(2):472-84.
Zhou X, Smith AJH, Waterhouse A, Blin G, Malaguti M, Lin C-Y, Osorno R, Chambers I, Lowell S.  2013.  Hes1 desynchronizes differentiation of pluripotent cells by modulating STAT3 activity.Stem Cells. 31(8):1511-22.

2012

Devoy A, Bunton-Stasyshyn RKA, Tybulewicz VLJ, Smith AJH, Fisher EMC.  2012.  Genomically humanized mice: technologies and promises.Nat Rev Genet. 13(1):14-20.
Rostovskaya M, Fu J, Obst M, Baer I, Weidlich S, Wang H, Smith AJH, Anastassiadis K, A Stewart F.  2012.  Transposon-mediated BAC transgenesis in human ES cells.Nucleic Acids Res. 40(19):e150.
Lynch MD, Smith AJH, De Gobbi M, Flenley M, Hughes J, Vernimmen D, Ayyub H, Sharpe JA, Sloane-Stanley JA, Sutherland L et al..  2012.  An interspecies analysis reveals a key role for unmethylated CpG dinucleotides in vertebrate Polycomb complex recruitment.EMBO J. 31(2):317-29.

2011

Vernimmen D, Lynch MD, De Gobbi M, Garrick D, Sharpe JA, Sloane-Stanley JA, Smith AJH, Higgs DR.  2011.  Polycomb eviction as a new distant enhancer function.Genes Dev. 25(15):1583-8.
Nowell CS, Bredenkamp N, Tetélin S, Jin X, Tischner C, Vaidya HJayesh, Sheridan JM, Stenhouse FH, Heussen R, Smith AJH et al..  2011.  Foxn1 regulates lineage progression in cortical and medullary thymic epithelial cells but is dispensable for medullary sublineage divergence.PLoS Genet. 7(11):e1002348.

2010

Meek S, Buehr M, Sutherland L, Thomson AJ, Mullins JJ, Smith AJH, Burdon T.  2010.  Efficient gene targeting by homologous recombination in rat embryonic stem cells.PLoS One. 5(12):e14225.

2009

Lippuner C, Paape D, Paterou A, Brand J, Richardson M, Smith AJH, Hoffmann K, Brinkmann V, C Blackburn C, Aebischer T.  2009.  Real-time imaging of Leishmania mexicana-infected early phagosomes: a study using primary macrophages generated from green fluorescent protein-Rab5 transgenic mice.FASEB J. 23(2):483-91.
Vernimmen D, Marques-Kranc F, Sharpe JA, Sloane-Stanley JA, Wood WG, Wallace HAC, Smith AJH, Higgs DR.  2009.  Chromosome looping at the human alpha-globin locus is mediated via the major upstream regulatory element (HS -40).Blood. 114(19):4253-60.
Al-Qassab H, Smith MA, Irvine EE, Guillermet-Guibert J, Claret M, Choudhury AI, Selman C, Piipari K, Clements M, Lingard S et al..  2009.  Dominant role of the p110beta isoform of PI3K over p110alpha in energy homeostasis regulation by POMC and AgRP neurons.Cell Metab. 10(5):343-54.

2008

Brown JM, Green J, Neves RPires das, Wallace HAC, Smith AJH, Hughes J, Gray N, Taylor S, Wood WG, Higgs DR et al..  2008.  Association between active genes occurs at nuclear speckles and is modulated by chromatin environment.J Cell Biol. 182(6):1083-97.
Graupera M, Guillermet-Guibert J, Foukas LC, Phng L-K, Cain RJ, Salpekar A, Pearce W, Meek S, Millan J, Cutillas PR et al..  2008.  Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration.Nature. 453(7195):662-6.
Guillermet-Guibert J, Bjorklof K, Salpekar A, Gonella C, Ramadani F, Bilancio A, Meek S, Smith AJH, Okkenhaug K, Vanhaesebroeck B.  2008.  The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma.Proc Natl Acad Sci U S A. 105(24):8292-7.

2007

Mahajan S, Cervera A, MacLeod M, Fillatreau S, Perona-Wright G, Meek S, Smith AJH, MacDonald A, Gray D.  2007.  The role of ICOS in the development of CD4 T cell help and the reactivation of memory T cells.Eur J Immunol. 37(7):1796-808.
Gironella M, Folch-Puy E, LeGoffic A, Garcia S, Christa L, Smith AJH, Tebar L, Hunt SP, Bayne R, Smith AJH et al..  2007.  Experimental acute pancreatitis in PAP/HIP knock-out mice.Gut. 56(8):1091-7.
Wallace HAC, Marques-Kranc F, Richardson M, Luna-Crespo F, Sharpe JA, Hughes J, Wood WG, Higgs DR, Smith AJH.  2007.  Manipulating the mouse genome to engineer precise functional syntenic replacements with human sequence.Cell. 128(1):197-209.

2006

Garrick D, Sharpe JA, Arkell R, Dobbie L, Smith AJH, Wood WG, Higgs DR, Gibbons RJ.  2006.  Loss of Atrx affects trophoblast development and the pattern of X-inactivation in extraembryonic tissues.PLoS Genet. 2(4):e58.
Foukas LC, Claret M, Pearce W, Okkenhaug K, Meek S, Peskett E, Sancho S, Smith AJH, Withers DJ, Vanhaesebroeck B.  2006.  Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation.Nature. 441(7091):366-70.

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