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Haematopoietic stem cells and leukaemia group publications

2018

O'Duibhir E, Paris J, Lawson H, Sepulveda C, Shenton DDoughty, Carragher NO, Kranc KR.  2018.  Machine Learning Enables Live Label-Free Phenotypic Screening in Three Dimensions.Assay Drug Dev Technol. 16(1):51-63.

2017

Guitart A, Panagopoulou TI, Villacreces A, Vukovic M, Sepulveda C, Allen L, Carter RN, van de Lagemaat LN, Morgan M, Giles P et al..  2017.  Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions.J Exp Med. 214(3):719-735.

2016

Woodward J, Taylor GC, Soares DC, Boyle S, Sie D, Read D, Chathoth K, Vukovic M, Tarrats N, Jamieson D et al..  2016.  Condensin II mutation causes T-cell lymphoma through tissue-specific genome instability.Genes Dev.
Karvela M, Baquero P, Kuntz EM, Mukhopadhyay A, Mitchell R, Allan EK, Chan E, Kranc KR, Calabretta B, Salomoni P et al..  2016.  ATG7 regulates energy metabolism, differentiation and survival of Philadelphia-chromosome-positive cells.Autophagy. :1-13.
Sinclair A, Park L, Shah M, Drotar M, Calaminus S, Hopcroft LEM, Kinstrie R, Guitart A, Dunn K, Abrahams S et al..  2016.  CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells.Blood.
Vukovic M, Sepulveda C, Subramani C, Guitart A, Mohr J, Allen L, Panagopoulou TI, Paris J.K, Lawson H, Villacreces A et al..  2016.  Adult haematopoietic stem cells lacking Hif-1α self-renew normally.Blood.

2015

Kranc KR, Dzierzak E.  2015.  Relieving oxidative stress in immune cells.J Exp Med. 212(8):1140.
Kranc KR, Oliveira DV, Armesilla-Diaz A, Pacheco-Leyva I, Matias ACatarina, Escapa ALuisa, Subramani C, Wheadon H, Trindade M, Nichols J et al..  2015.  Acute Loss of Cited2 Impairs Nanog Expression and Decreases Self-Renewal of Mouse Embryonic Stem CellsSTEM CELLS. 33(3):699-712.
Vukovic M, Guitart A, Sepulveda C, Villacreces A, O'Duibhir E, Panagopoulou TI, Ivens A, Menendez-Gonzalez J, Iglesias JManuel, Allen L et al..  2015.  Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance.J Exp Med. 212(13):2223-34.

2014

Gezer D, Vukovic M, Soga T, Pollard PJ, Kranc KR.  2014.  Concise Review: Genetic Dissection of Hypoxia Signaling Pathways in Normal and Leukemic Stem CellsSTEM CELLS. 32(6):1390-1397.
Pollard P, Yang M, Su H, Soga T, Kranc KR.  2014.  Prolyl hydroxylase domain enzymes: important regulators of cancer metabolismHypoxia. :127.

2013

Guitart A, Subramani C, Armesilla-Diaz A, Smith G, Sepulveda C, Gezer D, Vukovic M, Dunn K, Pollard P, Holyoake TL et al..  2013.  Hif-2α is not essential for cell-autonomous hematopoietic stem cell maintenance.Blood. 122(10):1741-5.

2012

Calaminus SDJ, Guitart A, Guitart A, Sinclair A, Schachtner H, Watson SP, Holyoake TL, Kranc KR, Machesky LM.  2012.  Lineage tracing of Pf4-Cre marks hematopoietic stem cells and their progeny.PLoS One. 7(12):e51361.

2011

Mortensen M, Soilleux EJ, Djordjevic G, Tripp R, Lutteropp M, Sadighi-Akha E, Stranks AJ, Glanville J, Knight S, Jacobsen S-EW et al..  2011.  The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance.J Exp Med. 208(3):455-67.

2010

Pollard PJ, Kranc KR.  2010.  Hypoxia signaling in hematopoietic stem cells: a double-edged sword.Cell Stem Cell. 7(3):276-8.

2009

Harkiolaki M, Holmes SL, Svendsen P, Gregersen JW, Jensen LT, McMahon R, Friese MA, van Boxel G, Etzensperger R, Tzartos JS et al..  2009.  T cell-mediated autoimmune disease due to low-affinity crossreactivity to common microbial peptides.Immunity. 30(3):348-57.
Kranc KR, Schepers H, Rodrigues NP, Bamforth S, Villadsen E, Ferry H, Bouriez-Jones T, Sigvardsson M, Bhattacharya S, Jacobsen SEirik et al..  2009.  Cited2 is an essential regulator of adult hematopoietic stem cells.Cell Stem Cell. 5(6):659-65.

2006

Gregersen JW, Kranc KR, Ke X, Svendsen P, Madsen LS, Thomsen ARandrup, Cardon LR, Bell JI, Fugger L.  2006.  Functional epistasis on a common MHC haplotype associated with multiple sclerosis.Nature. 443(7111):574-7.

2005

Kranc KR, Taylor AM, Willcox N, Fugger L.  2005.  Control of autoimmunity by "epitope theft".Trends Mol Med. 11(1):1-4.

2003

Kranc KR, Bamforth SD, Bragança J, Norbury C, van Lohuizen M, Bhattacharya S.  2003.  Transcriptional coactivator Cited2 induces Bmi1 and Mel18 and controls fibroblast proliferation via Ink4a/ARF.Mol Cell Biol. 23(21):7658-66.

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