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Embryonic stem cell biology group publications

2018

Barakat TStefan, Halbritter F, Zhang M, Rendeiro AF, Perenthaler E, Bock C, Chambers I.  2018.  Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells.Cell Stem Cell. 23(2):276-288.e8.
Mistri TKumar, Arindrarto W, Ng WPing, Wang C, Lim LHiong, Sun L, Chambers I, Wohland T, Robson P.  2018.  Dynamic changes in Sox2 spatio-temporal expression promote the second cell fate decision through/signaling in preimplantation mouse embryos.Biochem J. 475(6):1075-1089.
Zhang M, Leitch HG, Tang WWC, Festuccia N, Hall-Ponsele E, Nichols J, M Surani A, Smith A, Chambers I.  2018.  Esrrb Complementation Rescues Development of Nanog-Null Germ Cells.Cell Rep. 22(2):332-339.

2017

Acampora D, Di Giovannantonio LGiovanni, Garofalo A, Nigro V, Omodei D, Lombardi A, Zhang J, Chambers I, Simeone A.  2017.  Functional Antagonism between OTX2 and NANOG Specifies a Spectrum of Heterogeneous Identities in Embryonic Stem Cells.Stem Cell Reports. 9(5):1642-1659.
Corsinotti A, Wong FCk, Tatar T, Szczerbinska I, Halbritter F, Colby D, Gogolok S, Pantier R, Liggat K, Mirfazeli ES et al..  2017.  Distinct SoxB1 networks are required for naïve and primed pluripotency.Elife. 6
Pantier R, Mullin NP, Chambers I.  2017.  A new twist to Sin3 complexes in pluripotent cells.EMBO J.

2016

Mullin NP, Gagliardi A, Khoa LTran Phuc, Colby D, Hall-Ponsele E, Rowe AJ, Chambers I.  2016.  Distinct Contributions of Tryptophan Residues within the Dimerization Domain to Nanog Function.J Mol Biol.
Novo CLopes, Tang C, Ahmed K, Djuric U, Fussner E, Mullin NP, Morgan NP, Hayre J, Sienerth AR, Elderkin S et al..  2016.  The pluripotency factor Nanog regulates pericentromeric heterochromatin organization in mouse embryonic stem cells.Genes Dev. 30(9):1101-15.
Illich DJacob, Zhang M, Ursu A, Osorno R, Kim K-P, Yoon J, Araúzo-Bravo MJ, Wu G, Esch D, Sabour D et al..  2016.  Distinct Signaling Requirements for the Establishment of ESC Pluripotency in Late-Stage EpiSCs.Cell Reports. (15):1-14.

2015

Chantzoura E, Skylaki S, Menendez S, Kim S-I, Johnsson A, Linnarsson S, Woltjen K, Chambers I, Kaji K.  2015.  Reprogramming Roadblocks Are System Dependent.Stem Cell Reports. 5(3):350-64.
Mistri TKumar, Devasia AGeorge, Chu LThean, Ng WPing, Halbritter F, Colby D, Martynoga B, Tomlinson SR, Chambers I, Robson P et al..  2015.  Selective influence of Sox2 on POU transcription factor binding in embryonic and neural stem cells.EMBO Rep.

2014

Torres-Padilla M-E, Chambers I.  2014.  Transcription factor heterogeneity in pluripotent stem cells: a stochastic advantage.Development. 141(11):2173-81.

2013

Karwacki-Neisius V, Göke J, Osorno R, Halbritter F, Ng JHui, Weiße AY, Wong F, Gagliardi A, Mullin NP, Festuccia N et al..  2013.  Reduced Oct4 expression directs a robust pluripotent state with distinct signaling activity and increased enhancer occupancy by Oct4 and Nanog.Cell Stem Cell. 12(5):531-45.
Gagliardi A, Mullin NP, Tan ZYing, Colby D, Kousa AI, Halbritter F, Weiss JT, Felker A, Bezstarosti K, Favaro R et al..  2013.  A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.EMBO J. 32(16):2231-47.
Festuccia N, Osorno R, Wilson V, Chambers I.  2013.  The role of pluripotency gene regulatory network components in mediating transitions between pluripotent cell states.Curr Opin Genet Dev. 23(5):504-11.
Zhou X, Smith AJH, Waterhouse A, Blin G, Malaguti M, Lin C-Y, Osorno R, Chambers I, Lowell S.  2013.  Hes1 desynchronizes differentiation of pluripotent cells by modulating STAT3 activity.Stem Cells. 31(8):1511-22.
de Wit E, Bouwman BAM, Zhu Y, Klous P, Splinter E, Verstegen MJAM, Krijger PHL, Festuccia N, Nora EP, Welling M et al..  2013.  The pluripotent genome in three dimensions is shaped around pluripotency factors.Nature. 501(7466):227-31.

2012

Osorno R, Tsakiridis A, Wong F, Cambray N, Economou C, Wilkie R, Blin G, Scotting PJ, Chambers I, Wilson V.  2012.  The developmental dismantling of pluripotency is reversed by ectopic Oct4 expression.Development. 139(13):2288-98.
Navarro P, Festuccia N, Colby D, Gagliardi A, Mullin NP, Zhang W, Karwacki-Neisius V, Osorno R, Kelly D, Robertson M et al..  2012.  OCT4/SOX2-independent Nanog autorepression modulates heterogeneous Nanog gene expression in mouse ES cells.EMBO J. 31(24):4547-62.

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