Leading science, pioneering therapies

Developmental origins of blood stem cells and leukaemia group publications

2018

Ottersbach K, Sanjuan-Pla A., Torres-Ruíz R., Bueno C., Velasco-Hernández T., Menendez P..  2018.  The “never-ending” mouse models for MLL-rearranged acute leukemia are still teaching usHemaSphere. 2(4)(e57)
Crosby A, Toshner MR, Southwood MR, Soon E, Dunmore BJ, Groves E, Moore S, Wright P, Ottersbach K, Bennett C et al..  2018.  Hematopoietic stem cell transplantation alters susceptibility to pulmonary hypertension in Bmpr2-deficient mice.Pulm Circ. 8(4):2045894018801642.

2017

Malouf C, Ottersbach K.  2017.  Molecular processes involved in B cell acute lymphoblastic leukaemia.Cell Mol Life Sci.

2016

Barrett NA, Malouf C, Kapeni C, Bacon WA, Giotopoulos G, Jacobsen SEirik W, Huntly BJ, Ottersbach K.  2016.  Mll-AF4 Confers Enhanced Self-Renewal and Lymphoid Potential during a Restricted Window in Development.Cell Rep. 16(4):1039-54.
Mascarenhas MI, Bacon WA, Kapeni C, Fitch SR, Kimber G, Cheng SWPriscill, Li J, Green AR, Ottersbach K.  2016.  Analysis of Jak2 signaling reveals resistance of mouse embryonic hematopoietic stem cells to myeloproliferative disease mutation.Blood. 127((19)):2298-309.

2015

Rao TNageswara, Marks-Bluth J, Sullivan J, Gupta MK, Chandrakanthan V, Fitch SR, Ottersbach K, Jang YC, Piao X, Kulkarni RN et al..  2015.  High-level Gpr56 expression is dispensable for the maintenance and function of hematopoietic stem and progenitor cells in mice.Stem Cell Res. 14(3):307-22.
Marks-Bluth J, Khanna A, Chandrakanthan V, Thoms J, Bee T, Eich C, Kang YChan, Knezevic K, Qiao Q, Fitch S et al..  2015.  SMAD1 and SMAD5 Expression Is Coordinately Regulated by FLI1 and GATA2 during Endothelial Development.Mol Cell Biol. 35(12):2165-72.

2014

2013

Diffner E, Beck D, Gudgin E, Thoms JAI, Knezevic K, Pridans C, Foster S, Goode D, Lim WKhong, Boelen L et al..  2013.  Activity of a heptad of transcription factors is associated with stem cell programs and clinical outcome in acute myeloid leukemia.Blood. 121(12):2289-300.
Mirshekar-Syahkal B, Haak E, Kimber GM, van Leusden K, Harvey K, O'Rourke J, Laborda J, Bauer SR, de Bruijn MFTR, Ferguson-Smith AC et al..  2013.  Dlk1 is a negative regulator of emerging hematopoietic stem and progenitor cells.Haematologica. 98(2):163-71.
Malouf C, Ottersbach K.  2013.  The unconventional embryo: immune-restricted potential precedes multipotentiality.Cell Stem Cell. 13(5):509-10.

2012

Spensberger D, Kotsopoulou E, Ferreira R, Broccardo C, Scott LM, Fourouclas N, Ottersbach K, Green AR, Göttgens B.  2012.  Deletion of the Scl +19 enhancer increases the blood stem cell compartment without affecting the formation of mature blood lineages.Exp Hematol. 40(7):588-598.e1.
Fitch SR, Kimber GM, Wilson NK, Parker A, Mirshekar-Syahkal B, Göttgens B, Medvinsky A, Dzierzak E, Ottersbach K.  2012.  Signaling from the sympathetic nervous system regulates hematopoietic stem cell emergence during embryogenesis.Cell Stem Cell. 11(4):554-66.

2011

Tijssen MR, Cvejic A, Joshi A, Hannah RL, Ferreira R, Forrai A, Bellissimo DC, S Oram H, Smethurst PA, Wilson NK et al..  2011.  Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators.Dev Cell. 20(5):597-609.
Robin C, Ottersbach K, Boisset J-C, Oziemlak A, Dzierzak E.  2011.  CD41 is developmentally regulated and differentially expressed on mouse hematopoietic stem cells.Blood. 117(19):5088-91.
Knezevic K, Bee T, Wilson NK, Janes ME, Kinston S, Polderdijk S, Kolb-Kokocinski A, Ottersbach K, Pencovich, iv N, Groner Y et al..  2011.  A Runx1-Smad6 rheostat controls Runx1 activity during embryonic hematopoiesis.Mol Cell Biol. 31(14):2817-26.

2010

Wilson NK, Timms RT, Kinston SJ, Cheng Y-H, S Oram H, Landry J-R, Mullender J, Ottersbach K, Göttgens B.  2010.  Gfi1 expression is controlled by five distinct regulatory regions spread over 100 kilobases, with Scl/Tal1, Gata2, PU.1, Erg, Meis1, and Runx1 acting as upstream regulators in early hematopoietic cells.Mol Cell Biol. 30(15):3853-63.
Ottersbach K, Dzierzak E.  2010.  The placenta as a haematopoietic organ.Int J Dev Biol. 54(6-7):1099-106.
Göttgens B, Ferreira R, Sanchez M-J, Ishibashi S, Li J, Spensberger D, Lefevre P, Ottersbach K, Chapman M, Kinston S et al..  2010.  cis-Regulatory remodeling of the SCL locus during vertebrate evolution.Mol Cell Biol. 30(24):5741-51.

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