Cell therapies aim to improve patient health by delivering cells with therapeutic potential. To provide physical support and to confine the treatment delivery vehicles (gels, bioscaffold) are used. There is currently no non-destructive way to assess the state of the cells (number, distribution, identity, and viability) within these vehicles. We investigate the use of non destructive technologies to assess the quality and safety in 3D bioscaffolds. These technologies address also the need to monitor in a time-lapse fashion “disease in a dish” models.
Our main research interest is the development of non destructive quantitative monitoring technologies for regenerative medicine to monitor cell distribution, viability and identity in 2D and 3D cell therapies delivery vehicles (film, scaffold, gels, matrices). These technologies will help us to establish a quality-control of cell-based products before they are used in the clinic. They also address the need for real-time monitoring of in vitro disease models.
We currently have projects on:
- Optical coherence tomography for tissue engineering and regenerative medicine
- Fourier-Domain optical coherence tomography
- Optical coherence microscopy
- Noninvasive biosensors and quantitative methods in medicine and biology
- Electric cell-substrate impedance sensing (ECIS, http://www.biophysics.com/)
- Common-path optical coherence phase microscopy
– live cell optical fluctuations