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The multi-faceted role of Gata3 in developmental haematopoiesis.

TitleThe multi-faceted role of Gata3 in developmental haematopoiesis.
Publication TypeJournal Article
Year of Publication2018
AuthorsZaidan N, Ottersbach K
JournalOpen Biol
Volume8
Issue11
Date Published2018 Nov 21
ISSN2046-2441
Abstract

The transcription factor Gata3 is crucial for the development of several tissues and cell lineages both during development as well as postnatally. This importance is apparent from the early embryonic lethality following germline Gata3 deletion, with embryos displaying a number of phenotypes, and from the fact that Gata3 has been implicated in several cancer types. It often acts at the level of stem and progenitor cells in which it controls the expression of key lineage-determining factors as well as cell cycle genes, thus being one of the main drivers of cell fate choice and tissue morphogenesis. Gata3 is involved at various stages of haematopoiesis both in the adult as well as during development. This review summarizes the various contributions of Gata3 to haematopoiesis with a particular focus on the emergence of the first haematopoietic stem cells in the embryo-a process that appears to be influenced by Gata3 at various levels, thus highlighting the complex nature of Gata3 action.

DOI10.1098/rsob.180152
Alternate JournalOpen Biol
PubMed ID30463912
PubMed Central IDPMC6282070
Publication institute
CRM