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Molecular processes involved in B cell acute lymphoblastic leukaemia.

TitleMolecular processes involved in B cell acute lymphoblastic leukaemia.
Publication TypeJournal Article
Year of Publication2017
AuthorsMalouf C, Ottersbach K
JournalCell Mol Life Sci
Date Published2017 Aug 17
ISSN1420-9071
Abstract

B cell leukaemia is one of the most frequent malignancies in the paediatric population, but also affects a significant proportion of adults in developed countries. The majority of infant and paediatric cases initiate the process of leukaemogenesis during foetal development (in utero) through the formation of a chromosomal translocation or the acquisition/deletion of genetic material (hyperdiploidy or hypodiploidy, respectively). This first genetic insult is the major determinant for the prognosis and therapeutic outcome of patients. B cell leukaemia in adults displays similar molecular features as its paediatric counterpart. However, since this disease is highly represented in the infant and paediatric population, this review will focus on this demographic group and summarise the biological, clinical and epidemiological knowledge on B cell acute lymphoblastic leukaemia of four well characterised subtypes: t(4;11) MLL-AF4, t(12;21) ETV6-RUNX1, t(1;19) E2A-PBX1 and t(9;22) BCR-ABL1.

DOI10.1007/s00018-017-2620-z
Alternate JournalCell. Mol. Life Sci.
PubMed ID28819864
Publication institute
CRM