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Liver development, regeneration, and carcinogenesis.

TitleLiver development, regeneration, and carcinogenesis.
Publication TypeJournal Article
Year of Publication2010
AuthorsKung JWC, Currie IS, Forbes SJ, Ross JA
JournalJ Biomed Biotechnol
Volume2010
Pagination984248
Date Published2010
ISSN1110-7251
KeywordsAnimals, Disease Models, Animal, Fetus, Humans, Liver, Liver Neoplasms, Liver Regeneration, Stem Cells
Abstract

The identification of putative liver stem cells has brought closer the previously separate fields of liver development, regeneration, and carcinogenesis. Significant overlaps in the regulation of these processes are now being described. For example, studies in embryonic liver development have already provided the basis for directed differentiation of human embryonic stem cells and induced pluripotent stem cells into hepatocyte-like cells. As a result, the understanding of the cell biology of proliferation and differentiation in the liver has been improved. This knowledge can be used to improve the function of hepatocyte-like cells for drug testing, bioartificial livers, and transplantation. In parallel, the mechanisms regulating cancer cell biology are now clearer, providing fertile soil for novel therapeutic approaches. Recognition of the relationships between development, regeneration, and carcinogenesis, and the increasing evidence for the role of stem cells in all of these areas, has sparked fresh enthusiasm in understanding the underlying molecular mechanisms and has led to new targeted therapies for liver cirrhosis and primary liver cancers.

DOI10.1155/2010/984248
Alternate JournalJ. Biomed. Biotechnol.
PubMed ID20169172
PubMed Central IDPMC2821627
Grant ListG0800455 / / Medical Research Council / United Kingdom
/ / Medical Research Council / United Kingdom