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Induced pluripotent stem cell technology and stem cell therapy for diabetes.

TitleInduced pluripotent stem cell technology and stem cell therapy for diabetes.
Publication TypeJournal Article
Year of Publication2011
AuthorsDrummond RJ, Kunath T, Mee PJ, Ross JA
JournalExp Ther Med
Volume2
Issue1
Pagination3-7
Date Published2011 1
ISSN1792-0981
Abstract

Although diabetes can be managed clinically with the use of insulin injections, it remains an incurable and inconvenient disorder. In the long-term, it is associated with a number of clinical complications, such as cardiovascular disease, resulting in a desire for the development of new methodologies to replace defective cells and provide a lasting normality without the need for drug treatment. Stem cells, including induced pluripotent stem cells, offer the possibility of generating cells suitable for transplantation due to their capacity to differentiate into all tissue lineages. However, many issues must be addressed before this type of treatment becomes a reality, including the need for a greater understanding of the underlying biology involved in the onset of diabetes.

DOI10.3892/etm.2010.173
Alternate JournalExp Ther Med
PubMed ID22977463
PubMed Central IDPMC3440679
Grant ListG0901969 / / Medical Research Council / United Kingdom
Publication institute
CRM