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Genomically humanized mice: technologies and promises.

TitleGenomically humanized mice: technologies and promises.
Publication TypeJournal Article
Year of Publication2012
AuthorsDevoy A, Bunton-Stasyshyn RKA, Tybulewicz VLJ, Smith AG, Fisher EMC
JournalNat Rev Genet
Volume13
Issue1
Pagination14-20
Date Published2012 Jan
ISSN1471-0064
KeywordsAnimals, Chromosomes, Artificial, Mammalian, Disease Models, Animal, Gene Targeting, Gene Transfer Techniques, Genetic Diseases, Inborn, Genome-Wide Association Study, Humans, Mice, Mice, Transgenic, Promoter Regions, Genetic, Recombination, Genetic, Regulatory Elements, Transcriptional, Transgenes
Abstract

Mouse models have become an invaluable tool for understanding human health and disease owing to our ability to manipulate the mouse genome exquisitely. Recent progress in genomic analysis has led to an increase in the number and type of disease-causing mutations detected and has also highlighted the importance of non-coding regions. As a result, there is increasing interest in creating 'genomically' humanized mouse models, in which entire human genomic loci are transferred into the mouse genome. The technical challenges towards achieving this aim are large but are starting to be tackled with success.

DOI10.1038/nrg3116
Alternate JournalNat. Rev. Genet.
PubMed ID22179716
Grant ListG0601056 / / Medical Research Council / United Kingdom
G0801110 / / Medical Research Council / United Kingdom
MC_U117527252 / / Medical Research Council / United Kingdom
/ / Medical Research Council / United Kingdom
/ / Wellcome Trust / United Kingdom