Leading science, pioneering therapies
CRM Publications

Endothelial cell-oligodendrocyte interactions in small vessel disease and aging.

TitleEndothelial cell-oligodendrocyte interactions in small vessel disease and aging.
Publication TypeJournal Article
Year of Publication2017
AuthorsRajani RM, Williams AC
JournalClin Sci (Lond)
Volume131
Issue5
Pagination369-379
Date Published2017 Mar 01
ISSN1470-8736
KeywordsAging, Animals, Cell Communication, Cerebral Small Vessel Diseases, Disease Models, Animal, Endothelial Cells, Humans, Oligodendroglia
Abstract

Cerebral small vessel disease (SVD) is a prevalent, neurological disease that significantly increases the risk of stroke and dementia. The main pathological changes are vascular, in the form of lipohyalinosis and arteriosclerosis, and in the white matter (WM), in the form of WM lesions. Despite this, it is unclear to what extent the key cell types involved-the endothelial cells (ECs) of the vasculature and the oligodendrocytes of the WM-interact. Here, we describe the work that has so far been carried out suggesting an interaction between ECs and oligodendrocytes in SVD. As these interactions have been studied in more detail in other disease states and in development, we explore these systems and discuss the role these mechanisms may play in SVD.

DOI10.1042/CS20160618
Alternate JournalClin. Sci.
PubMed ID28202749
PubMed Central IDPMC5310718
Publication institute
CRM