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The devil is in the mesoscale: Mechanical and behavioural heterogeneity in collective cell movement.

TitleThe devil is in the mesoscale: Mechanical and behavioural heterogeneity in collective cell movement.
Publication TypeJournal Article
Year of Publication2018
AuthorsBlanchard GB, Fletcher AG, Schumacher LJ
JournalSemin Cell Dev Biol
Date Published2018 Jun 27
ISSN1096-3634
Abstract

Heterogeneity within cell populations can be an important aspect affecting their collective movement and tissue-mechanical properties, determining for example their effective viscoelasticity. Differences in cell-level properties and behaviour within a group of moving cells can give rise to unexpected and non-intuitive behaviours at the tissue level. Such emergent phenomena often manifest themselves through spatiotemporal patterns at an intermediate 'mesoscale' between cell and tissue scales, typically involving tens of cells. Focussing on the development of embryonic animal tissues, we review recent evidence for the importance of heterogeneity at the mesoscale for collective cell migration and convergence and extension movements. We further discuss approaches to incorporate heterogeneity into computational models to complement experimental investigations.

DOI10.1016/j.semcdb.2018.06.003
Alternate JournalSemin. Cell Dev. Biol.
PubMed ID29940338
Publication institute
CRM