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Could pericytic mimicry represent another type of melanoma cell plasticity with embryonic properties?

TitleCould pericytic mimicry represent another type of melanoma cell plasticity with embryonic properties?
Publication TypeJournal Article
Year of Publication2013
AuthorsLugassy C, Péault B, Wadehra M, Kleinman HK, Barnhill RL
JournalPigment Cell Melanoma Res
Volume26
Issue5
Pagination746-54
Date Published2013 Sep
ISSN1755-148X
KeywordsAnimals, Cell Movement, Humans, Melanoma, Molecular Mimicry, Neovascularization, Pathologic, Neural Crest, Pericytes, Skin Neoplasms
Abstract

We hypothesize that the interaction between angiotropic melanoma cells and the abluminal vascular surface can induce or sustain embryonic and/or stem cell migratory properties in these tumor cells. As a result, such angiotropic melanoma cells may migrate along the abluminal vascular surface, demonstrating pericytic mimicry. Through these cellular interactions, melanoma cells may migrate toward secondary sites.

DOI10.1111/pcmr.12120
Alternate JournalPigment Cell Melanoma Res
PubMed ID23789776
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