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Chromatin folding and nuclear architecture: PRC1 function in 3D.

TitleChromatin folding and nuclear architecture: PRC1 function in 3D.
Publication TypeJournal Article
Year of Publication2019
AuthorsIllingworth R
JournalCurr Opin Genet Dev
Volume55
Pagination82-90
Date Published2019 Jul 16
ISSN1879-0380
Abstract

Embryonic development requires the intricate balance between the expansion and specialisation of defined cell types in time and space. The gene expression programmes that underpin this balance are regulated, in part, by modulating the chemical and structural state of chromatin. Polycomb repressive complexes (PRCs), a family of essential developmental regulators, operate at this level to stabilise or perpetuate a repressed but transcriptionally poised chromatin configuration. This dynamic state is required to control the timely initiation of productive gene transcription during embryonic development. The two major PRCs cooperate to target the genome, but it is PRC1 that appears to be the primary effector that controls gene expression. In this review I will discuss recent findings relating to how PRC1 alters chromatin accessibility, folding and global 3D nuclear organisation to control gene transcription.

DOI10.1016/j.gde.2019.06.006
Alternate JournalCurr. Opin. Genet. Dev.
PubMed ID31323466
Publication institute
CRM