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Cellular Origin and Functional Relevance of Collagen I Production in the Kidney.

TitleCellular Origin and Functional Relevance of Collagen I Production in the Kidney.
Publication TypeJournal Article
Year of Publication2018
AuthorsBuchtler S, Grill A, Hofmarksrichter S, Stöckert P, Schiechl-Brachner G, Gomez MRodriguez, Neumayer S, Schmidbauer K, Talke Y, Klinkhammer BM, Boor P, Medvinsky A, Renner K, Castrop H, Mack M
JournalJ Am Soc Nephrol
Volume29
Issue7
Pagination1859-1873
Date Published2018 Jul
ISSN1533-3450
Abstract

Interstitial fibrosis is associated with chronic renal failure. In addition to fibroblasts, bone marrow-derived cells and tubular epithelial cells have the capacity to produce collagen. However, the amount of collagen produced by each of these cell types and the relevance of fibrosis to renal function are unclear. We generated conditional cell type-specific collagen I knockout mice and used (reversible) unilateral ureteral obstruction and adenine-induced nephropathy to study renal fibrosis and function. In these mouse models, hematopoietic, bone marrow-derived cells contributed to 38%-50% of the overall deposition of collagen I in the kidney. The influence of fibrosis on renal function was dependent on the type of damage. In unilateral ureteral obstruction, collagen production by resident fibroblasts was essential to preserve renal function, whereas in the chronic model of adenine-induced nephropathy, collagen production was detrimental to renal function. Our data show that hematopoietic cells are a major source of collagen and that antifibrotic therapies need to be carefully considered depending on the type of disease and the underlying cause of fibrosis.

DOI10.1681/ASN.2018020138
Alternate JournalJ. Am. Soc. Nephrol.
PubMed ID29777019
PubMed Central IDPMC6050926
Publication institute
CRM