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Ang-2 but not Ang-1 expression in perivascular soft tissue tumors.

TitleAng-2 but not Ang-1 expression in perivascular soft tissue tumors.
Publication TypeJournal Article
Year of Publication2017
AuthorsShrestha S, Shen J, Giacomelli P, Scott MA, Soo C, Ting K, Péault B, Dry SM, James AW
JournalJ Orthop
Volume14
Issue1
Pagination147-153
Date Published2017 Mar
Abstract

Perivascular soft tissue tumors are relatively uncommon neoplasms of unclear line of differentiation, although most are presumed to originate from pericytes. Previously, we reported a shared immunophenotype across these related tumor types. Here, we extend these findings to examine the expression of the pericyte markers angiopoietin-1 and -2 (Ang-1 and -2) among perivascular soft tissue tumors. Results showed consistent Ang-2 but not Ang-1 expression across tumor types. In summary, the absence of Ang-1 expression distinguishes perivascular from vascular soft tissue tumors. Ang-2 expression is present across perivascular soft tissue tumors, with some variation between histologic subtypes.

DOI10.1016/j.jor.2016.07.003
Alternate JournalJ Orthop
PubMed ID27942190
PubMed Central IDPMC5134090
Grant ListK08 AR068316 / AR / NIAMS NIH HHS / United States
Publication institute
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